BIOGRAPHICAL SKETCH

NAME:

Charles J. Hoff, Ph.D.

POSITION TITLE:

Professor of Pediatrics and Biostatistics & Epidemiology

EDUCATION/TRAINING:

INSTITUTION AND LOCATION:

DEGREE:

YEAR(s):

FIELD OF STUDY:

Pennsylvania State University, University Park, PA

B.S.

1961

Appl. Mathematics.
Pennsylvania State University, University Park, PA

M.A.

1968

Biol. Anthropology
University of Oxford, Oxford, ENGLAND

Dipl. (*)

1968

Human Biology.
Pennsylvania State University, University Park, PA

Ph.D.

1972

Biol. Anthropology

(*M.S. equivalent) (**3 week courses) (***1 week course)

POST-DOCTORAL EDUCATION:

Epidemiology & Biostatistics: Univ. Massachusetts, Amherst; Univ. Minn., Minneapolis, 1984; 1986 (**)

Immunology: Lindenwood College, St. Charles, Missouri, 1987 (***)

PROFESSIONAL EXPERIENCE:

1962-64 Systems Engineer/Computer Programmer, IBM, Endicott, NY,

1968-69 Research Associate/Instructor, Anthropology, Pennsylvania State Univ., University Park, PA

1970-76 Assistant Professor, Anthropology, University of Oregon, Eugene, OR

1976-86/1986-88 Associate Professor/Professor, Medical Genetics, University of South Alabama, Mobile, AL

1988-90 Staff Scientist, Epidemiology & Biometry, Battelle Pacific Northwest Laboratories, Richland, WA

1989-90 Clinical Associate Professor, Epidemiology, University of Washington, Seattle, WA

1990-Present Professor, Pediatrics, College of Medicine, University of South Alabama, Mobile, AL

1992-Present Professor, Biostatistics & Epidemiology, University of South Alabama, COM, Mobile, AL

1996-Present Biostatistics Consultant, University of South Alabama Comprehensive Sickle Cell Center

SELECTED PROFESSIONAL SOCIETY MEMBERSHIP (out of 8):

Society for Epidemiologic Research, American Society for Reproductive Immunology, American College of Epidemiology (Fellow), Human Biology Association (Fellow)

SELECTED EXTRAMURAL GRANTS as P.I. (out of 6 as p.i. or co-i.), AWARDS, and HONORS:

NIH Grants: HD11637: 1979-81 (Adolescent Pregnancy) and HD21144: 1986-88 (Maternofetal Immunogenetic Relationships & Pregnancy Outcome); Wenner-Gren Fellow (Oxford): 1967-68; NIH Trainee: 1969; MBRS Visiting Professor: University of Hawaii: March 1992; NIH ad hoc study sections: AIDS&RR (2) and MBRS (2); biographical listing: American Men and Women of Science, 15th-current ed. and International Who’s Who in Medicine, 2nd ed., Editorial Board: Amer J Hum Biol: 1989-1995

SELECTED PUBLICATIONS (out of ~100):

Hoff C: Altitudinal variation in the physical growth and development of Peruvian Quechua. Homo 24: 87-99, 1974.

Hoff C, Blackburn WR: A multivariate discriminant method for comparing growth data in a study group with age-matched means and standard deviations from a control group. Hum Biol 53:513-20, 1981.

Peevy KJ, Grant PH, Hoff C: Capillary venous differences in neonatal neutrophil values. Am J Dis Child 136: 357-8, 1982.

Hoff C, Wertelecki W, Dutt J Hernandez R, Reyes E, Sharp M: Sickle cell trait, maternal age and pregnancy outcome in primiparous women. Hum Biol 55:763-70, 1983.

Hoff C, Bixler C: Maternofetal ABO antigenic dissimilarity and the development of pre-eclampsia (letter). Lancet ii: 729-30, 1984.

Hoff C, Wertelecki W, Zansky S, Reyes E, Dutt J, Stumpe AR: Earlier maturation of pregnant black and white adolescents. Am J Dis Child 139: 981-6, 1985.

Hoff C: Chi-square trend analysis in antigen sharing studies. Tissue Antigens 26: 212-3, 1985.

Peevy KJ, Speed FA, Hoff C: Epidemiology of inguinal hernia in preterm neonates. Pediatrics 77: 246-7,1986.

Hoff C, Wertelecki W, Reyes E, Dutt J, Stumpe AR, Schultz D: Diet, blood pressure, and hematological variables of nulliparous women attending a prenatal clinic. Obstet Gynecol 67: 868-72, 1986.

Hoff C, Bixler C: Maternal-fetal ABO/Rh antigenic dissimilarity and human fetal development. Am J Obstet Gynecol 153: 126-9, 1986.

Hoff C, Wertelecki W, Blackburn WR, Mendenhall H, Wiseman H, Stumpe AR: Trend associations of smoking with maternal, fetal and neonatal morbidity. Obstet Gynecol 68: 317-21, 1986.

Wertelecki W, Hoff C, Zansky S: Maternal smoking, greater effect on males, fetal tobacco syndrome? Teratology 35: 317-20, 1987.

Bastian FO, Jennings RA, Hoff C: Neurotropic response of Spiroplasma mirium following peripheral inoculation. Ann Inst Pasteur/Microbiol 138: 651-6, 1987.

Hoff C, Kitay D: Genetics of blood disorders. In Hematological Problems in Pregnancy, ed: Kitay D, Medical Economics Books, Oradell, NJ, 1987.

Powell RW, Blaylock WE, Hoff C, Chartrand SA: The protective effect of Pneumococcal vaccination following partial splenectomy. J Surg Res 45: 56-9, 1988.

Powell RW, Blaylock WE, Hoff C, Chartrand SA: The efficacy of postsplenectomy sepsis prophylactic measures: The role of penicillin. J Trauma 28: 1285-8, 1988.

Wertelecki W, Superneau D, Forehand L, Hoff C: Angiomas and von Recklinghausen neurofibromatosis. Neurofibromatosis 2: 37-54, 1988.

Hoff C, Garruto RM, Durham N: Human adaptability and medical genetics. In Human Population Biology, eds: Little MA, Haas J, Oxford University Press, New York, NY, 1989.

Bastian FO, Jennings RA, Hoff C: Effect of Trimethoprim/sulphomethoxazole & hyperbaric oxygen on experimental Spiroplasma mirium encephalitis. Ann Inst Pasteur/Microbiol 140: 151-8, 1989.

Hoff C, Peterson RDA: Minireview: Does exposure to HLA alloantigens trigger immunoregulatory mechanisms operative in both pregnancy & AIDS? Life Sciences 45: iii-ix, 1989.

Embree J, Braddick M, Datta R, Murithi J, Hoff C, Kreiss JK, Roberts PL, Law BJ, Pamba HO, Ndinya-Achola JO, Plummer FA: Lack of correlation of maternal human immunodeficiency virus infection with neonatal malformations. Pediatr Infect Dis J 8: 700-4, 1989.

Hoff C, Stevens R, Mendenhall H, Peterson RDA, Spinnato JA: The association between risk for pre-eclampsia and HLA-DR4 (letter). Lancet ii: 660-1, 1990.

Hoff C, Peterson RDA: Lymphocyte alloantigenic challenge as a potential cofactor in HIV infection and progression to AIDS. Am J Hum Biol 2: 419-27, 1990.

Hoff C, James WC, Hester RB, Nolan P, Peterson RDA: Signs of cellular immunosuppression correlate with HLA-DR in healthy, HIV-negative homosexuals: Preliminary findings. Hum Biol 63: 129-35, 1991.

Smith S, Morris J, Hoff C, Davis W, Weller R: Immunophenotypic characterization of owl monkey peripheral blood mononuclear cells. Ann NY Acad Sci 653: 146-53, 1992.

Hoff C, Trimm RF, Thompson LW, Peevy KJ, Fancher KM: A cohort study of maternal HLA-DR homozygosity and increased risk for fetal loss. Am J Reprod Immunol 28: 17-9, 1992.

Hoff C, Peterson RDA, Peevy KJ, Spinnato J, Giattina K: Maternal-fetal HLA-DR relationships and pregnancy-induced hypertension. Obstet Gynecol 80: 1007-12, 1992

Gilmore SM, Aksel S, Hoff C, Peterson RDA: In vitro lymphocyte activity in women with endometriosis: An altered immune response? Fertil Steril 58: 1148-52, 1992

Hoff C, Shah A: Histocompatibility antigens and pregnancy (letter). Am J Obstet Gynecol 184: 1331, 1993

Hoff C, Peevy K, Spinnato J, Giattina K, Peterson RDA: Maternal-fetal HLA-DR relationships and fetal growth. Am J Reprod Immunol 30: 246-53, 1993.

Peterson RDA, Tuck-Muller C, Spinnato JA, Peevy K, Giattina K, Hoff C: An HLA-haplotype associated with preeclampsia and intrauterine growth retardation. Am J Reprod Immunol 31: 177-9, 1994.

Elliott M, Lee J, Hoff C, Ramsey KM, DeVivo V, King A, Holmes R, Eichold BH: Comparisons of risk factors for HIV-1 infection in Jefferson and Mobile County, Alabama. Am J Med Sci 309: 1-4, 1995.

Yang Y-M, Hoff C, Hamm C, Mankad V, Boerth R: Pharmacokinetics of meperidine in sickle cell patients. J Am Hematol 49: 357-8, 1995.

Hoff C, Peterson RDA: Fetal-maternal serum levels of immune activation markers and fetal growth. Am J Hum Biol 7: 453-8, 1995.

Hoff C, Trimm RF, Peevy KJ: Conflicting findings in the association of maternal HLA-DR homozygosity and fetal loss (letter). Dis Markers 13:65-7, 1996.

Hoff C: Histocompatibility antigens and pregnancy outcome revisited (letter). Am J Reprod Immunol 37:213-4, 1997.

Atterbury JL, Groome LJ, Hoff C: Clinical presentation of a woman readmitted with post partum severe preeclampsia or eclampsia. J. Obstet Gynecol Neonatal Nursing 27:134-41, 1998.

Werdehoff SG, Moore RB,  Hoff C, Fillingim E, Hackman AM : Elevated plasma endothelin-1  in sickle cell anemia: relationships to oxygen  saturation and left ventricular  
hypertrophy.   Am. J. Hematol.  58: 195-199, 1998.
Gremse DA, Fillingim E, Hoff C, Wells DJ, Boerth RC:  Hepatic function as assessed by  lidocaine in sickle cell disease.  J. Pediatr. 132: 989-993, 1998.
Atterbury JL, Groome LJ, Hoff C:  Methods used to diagnose premature ruptured  membranes: A national survey of 812 obstetrical nurses.  Obstet. Gynecol. (inpress).

Hoff C: Pregnancy, HLA allogeneic challenge, and implications for AIDS etiology. Med Hypoth (in press).

Hoff C: Book review: The Medical Management of AIDS in Women. Hum Biol (in press).

 

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