BIOGRAPHICAL SKETCH |
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| NAME |
POSITION TITLE |
|||
| EDUCATION/TRAINING | ||||
| INSTITUTION AND LOCATION | DEGREE | YEAR(s) |
FIELD OF STUDY |
|
| SUNY at Stony Brook | B.S. |
1971 |
Chemistry | |
| St. Louis University Medical School | Ph.D. |
1976 |
Biochemistry | |
| Harvard Medical School | Postdoc. |
1976-77 |
Molecular Biology | |
| Harvard University (Biological labs) | Postdoc. |
1977-79 |
Cell Biology | |
Professional Experience:
1979-83 Assistant Professor of Physiology, The Milton S. Hershey Medical Center, The Pennsylvania State University
1983-87 Associate Professor of Physiology, The Milton S. Hershey Medical Center, The Pennsylvania State University
1985-88 Director, The Cell and Molecular Biology Center, The Milton S. Hershey Medical Center, The Pennsylvania State University
1987-88 Professor of Physiology, The Milton S. Hershey Medical Center, The Pennsylvania State University
1979-88 Head of Multidisciplinary Laboratories, The Milton S. Hershey Medical Center, The Pennsylvania State University
1988-present Professor and Chairman, Department of Structural and Cellular Biology, University of South Alabama College of Medicine
1993-present Director, Comprehensive Sickle Cell Center, University of South Alabama College of Medicine
SELECTED PUBLICATIONS (out of 189):
Yu J. and S.R. Goodman. Syndeins: The Spectrin-binding Protein(s) of the Human Erythrocyte Membrane. Proc. Natl Acad. Sci. USA 1979;76:2340-2344.
Siegel D., S.R. Goodman and D. Branton. The Effect of Endogenous Proteases on the Spectrin Binding Proteins of Human Erythrocytes. Biochem. Biophys. Acta 1980;598:517-527.
and S.A. Weidner. Binding of Spectrin a2 - b2 Tetramers to Human Erythrocyte Membranes. J. Biol. Chem. 1980;255:8082-8086.Goodman S.R.
, I.S. Zagon and R.R. Kulikowski. Identification of a Spectrin-like Protein in Nonerythroid Cells. Proc. Natl Acad. Sci. USA 1981;78:7570-7574.Goodman S.R.
, J. Yu, C.F. Whitfield, E.N. Culp and E.J. Posnak. Erythrocyte Membrane Skeletal Proteins 4.1a and b are Sequence Related Phosphoproteins. J Biol. Chem. 1982;257:4564-4569.Goodman S.R.
, K.A. Shiffer, L.A. Casoria and M.E. Eyster. Identification of the Molecular Defect in the Erythrocyte Membrane Skeleton of Some Kindreds with Hereditary Spherocytosis. Blood 1982;60:772-784.Goodman S.R.
, and K.A. Shiffer. The Spectrin Membrane Skeleton of Normal and Abnormal Human Erythrocytes: A Review. Am. J. Physiol: Cell Physiol. 1983;244:C121-C141.Goodman S.R.
Kay M.M.B., S.R. Goodman, K. Sorensen, C.F. Whitfield, P. Wong, L. Zaki and V. Rudloff. Senescent Cell Antigen is Immunologically Related to Band 3. Proc. Natl Acad. Sci. USA 1983;80:1631-1635.
Wallin R., E.N. Culp, D.B. Coleman, and S.R. Goodman. A Structural Model of Human Erythrocyte Band 2.1: Alignment of Chemical and Functional Domains. Proc. Natl Acad. Sci. USA 1984;81:4095-4099.
Shiffer K.A. and S.R. Goodman. Protein 4.1: Its Association with the Human Erythrocyte Membrane Proc. Natl Acad. Sci. USA 1984;81:4404-4408.
Riederer B.M., I.S. Zagon and S.R. Goodman. Brain Spectrin (240/235) and Brain Spectrin (240/235E): Two Distinct Spectrin Subtypes with Different Locations within Mammalian Neural Cells. J. Cell. Biol. 1986;102:2088-2096.
b Spectrin cDNA. Blood 1987;70:915-920.Cioe L., P. Laurila, M. Pacifico, K. Krebs, S.R. Goodman and P.J. Curtis. Cloning and Nucleotide Sequence of a Mouse Erythrocyte-
b-Spectrin. J. Biol. Chem. 1990;265:11833-11840.Karinch A.M., W.E. Zimmer, and S.R. Goodman. The Identification and Sequence of the Acting-binding Domain of Human and Blood Cell
Yang Y.M., C. Donnell, W. Wilborn, S.R. Goodman, B. Files, R.B. Moore, N. Mohandas and V. Mankad. Splenic Sequestration Associated with Sickle Cell Trait and Hereditary Spherocytosis. Am. J. Hematol. 1992;40:110-116.
b-Spectrin (b-fodrin): Relationship to Globin Sequences. Mol. Brain Res. 1993;18:87-99.Ma Y., W.E. Zimmer, B.M. Riederer, M.L. Bloom, J.E. Barker and S.R. Goodman. The Complete Amino Acid Sequence for Brain
Lengeling A., W.E. Zimmer, S.R. Goodman, Y. Ma, M.L. Bloom, G. Gruneau, M. Krieger, J. Thibault, K. Kaupmann and H. Jockusch. Exclusion of two Candidate Genes, SpnB-2 and Ddc, for the Wobbler Spinal Muscular Atrophy Gene on Proximal Mouse Chromosome 11. Mammalian Genome 1994;5Z:163-166.
b-spectrin Association. Brain Research 1994;663:223-236.Clark M.B., Y. Ma, M. Bloom, J. Barker, I. Zagon, W.E. Zimmer, and S.R. Goodman. Brain b Erythroid Spectrin: Identification , Compartmentalization, and
b-actin Contributes to the Slow Dissociation of the Spectrin-Protein 4.1-Actin Complex of Irreversibly Sickled Cells. J. Cell Biol. 1995;128:805-815.Shartava A., C.A. Monteiro, F.A. Bencsath, K. Schneider, B.T. Chait, R. Gussio, L.A. Casoria-Scott, A.K. Shah, C.A. Heuerman and S.R. Goodman. A Posttranslational Modification of
., W.E. Zimmer, M.B. Clark, I.S. Zagon, J.E. Barker and M.L. Bloom. Brain Spectrin: Of Mice and Men. Brain Res. Bul. 1995;36:593-606.Goodman, S.R
Zimmer, W.E. and S.R. Goodman. Brain Spectrin. Encyclopedia Human Biol. (R. Dulbecco, Ed.) Academic Press, Vol. 3 (in press).
Shartava, A., P. Miranda, A. Shah, C.A. Monteiro and S.R. Goodman. High Density Sickle Cell Erythrocyte Core Membrane Skeletons Demonstrate Slow Temperature Dependent Dissociation. Am. J. Hematol. 1996;51:215-220.
The Role of the Membrane Skeleton in Formation of the Irreversibly Sickled Cell: A Review. Cellular & Molecular Biol. Letters 1996;1:105-112.Goodman, S.R.
b-Actin Disulfide-linked Peptide which Leads to the Slow Dissociation of the Irreversibly Sickled Membrane Skeleton. Biochemistry 1996;35:4403-4408.Bencsath, F.A., A. Shartava, C.A. Monteiro, and S.R. Goodman. Identification of the
Monteiro, C.A. and S.R. Goodman. Structural Defect in Irreversibly Sickled Cell Alpha Spectrin Demonstrated by a Rabbit Autoantibody. Blood (in press).
b-Actin: Defective Filament Formation. Am. J. Hematology 1997;55:97-103.Shartava, A., W. Korn and S.R. Goodman. Irreversibly Sickled Cell
Gibson, X.A., Y. Zhang, J. Mcintyre, A. Shah, N. Campbell, S.R. Goodmen. The Efficacy of Reducing Agents or Antioxidants in Blocking the Formation of Irreversibly Sickled Cells In Vitro Blood (inpress).
Wang, G., X. Xu, B.S. Pace, P.M. Glazer, P. Chan, I. Shokolenko, and S.R. Goodman. Inducing Endogenous Human g -Globin Gene Expression by Peptide Nucleic Acids (PNAs). Biochemistry (submitted).
Pace, B.S., Y.R. Chen, A. Thompson, and S.R. Goodman. Truncation Analysis of Butyrate Inducible Elements in the Human Ag Globin Gene Promoter. Journal of Biological Chemistry (submitted).
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