BIOGRAPHICAL SKETCH

NAME

Steven R. Goodman, Ph.D.

POSITION TITLE

Professor and Chairman

EDUCATION/TRAINING
INSTITUTION AND LOCATION DEGREE

YEAR(s)

FIELD OF STUDY

SUNY at Stony Brook

B.S.

1971

Chemistry
St. Louis University Medical School

Ph.D.

1976

Biochemistry
Harvard Medical School

Postdoc.

1976-77

Molecular Biology
Harvard University (Biological labs)

Postdoc.

1977-79

Cell Biology

Professional Experience:

1979-83              Assistant Professor of Physiology, The Milton S. Hershey Medical Center, The Pennsylvania State University

1983-87            Associate Professor of Physiology, The Milton S. Hershey Medical Center, The Pennsylvania State University

1985-88            Director, The Cell and Molecular Biology Center, The Milton S. Hershey Medical Center, The Pennsylvania State University

1987-88            Professor of Physiology, The Milton S. Hershey Medical Center, The Pennsylvania State University

1979-88            Head of Multidisciplinary Laboratories, The Milton S. Hershey Medical Center, The Pennsylvania State University

1988-present    Professor and Chairman, Department of Structural and Cellular Biology, University of South Alabama College of Medicine

1993-present    Director, Comprehensive Sickle Cell Center, University of South Alabama College of Medicine

SELECTED PUBLICATIONS (out of 189):

Yu J. and S.R. Goodman. Syndeins: The Spectrin-binding Protein(s) of the Human Erythrocyte Membrane. Proc. Nat’l  Acad. Sci. USA 1979;76:2340-2344.

Siegel D., S.R. Goodman and D. Branton. The Effect of Endogenous Proteases on the Spectrin Binding Proteins of  Human Erythrocytes. Biochem. Biophys. Acta 1980;598:517-527.

Goodman S.R. and S.A. Weidner. Binding of Spectrin a2 - b2 Tetramers to Human Erythrocyte Membranes. J. Biol. Chem. 1980;255:8082-8086.

Goodman S.R., I.S. Zagon and R.R. Kulikowski. Identification of a Spectrin-like Protein in Nonerythroid Cells. Proc. Nat’l  Acad. Sci. USA 1981;78:7570-7574.

Goodman S.R., J. Yu, C.F. Whitfield, E.N. Culp and E.J. Posnak. Erythrocyte Membrane Skeletal Proteins 4.1a and b are Sequence Related Phosphoproteins. J Biol. Chem. 1982;257:4564-4569.

Goodman S.R., K.A. Shiffer, L.A. Casoria and M.E. Eyster. Identification of the Molecular Defect in the Erythrocyte Membrane Skeleton of Some Kindreds with Hereditary Spherocytosis. Blood 1982;60:772-784.

Goodman S.R., and K.A. Shiffer. The Spectrin Membrane Skeleton of Normal and Abnormal Human Erythrocytes: A Review. Am. J. Physiol: Cell Physiol. 1983;244:C121-C141.

Kay M.M.B., S.R. Goodman, K. Sorensen, C.F. Whitfield, P. Wong, L. Zaki and V. Rudloff. Senescent Cell Antigen is Immunologically Related to Band 3. Proc. Nat’l Acad. Sci. USA 1983;80:1631-1635.

Wallin R., E.N. Culp, D.B. Coleman, and S.R. Goodman. A Structural Model of Human Erythrocyte Band 2.1: Alignment of Chemical and Functional Domains. Proc. Nat’l Acad. Sci. USA 1984;81:4095-4099.

Shiffer K.A. and S.R. Goodman. Protein 4.1: Its Association with the Human Erythrocyte Membrane Proc. Nat’l Acad. Sci. USA 1984;81:4404-4408.

Riederer B.M., I.S. Zagon and S.R. Goodman. Brain Spectrin (240/235) and Brain Spectrin (240/235E): Two Distinct Spectrin Subtypes with Different Locations within Mammalian Neural Cells. J. Cell. Biol. 1986;102:2088-2096.

Cioe L., P. Laurila, M. Pacifico, K. Krebs, S.R. Goodman and P.J. Curtis. Cloning and Nucleotide Sequence of a Mouse Erythrocyte-b Spectrin cDNA. Blood 1987;70:915-920.

Karinch A.M., W.E. Zimmer, and S.R. Goodman. The Identification and Sequence of the Acting-binding Domain of Human and Blood Cell b-Spectrin. J. Biol. Chem. 1990;265:11833-11840.

Yang Y.M., C. Donnell, W. Wilborn, S.R. Goodman, B. Files, R.B. Moore, N. Mohandas and V. Mankad. Splenic Sequestration Associated with Sickle Cell Trait and Hereditary Spherocytosis. Am. J. Hematol. 1992;40:110-116.

Ma Y., W.E. Zimmer, B.M. Riederer, M.L. Bloom, J.E. Barker and S.R. Goodman. The Complete Amino Acid Sequence for Brain b-Spectrin (b-fodrin): Relationship to Globin Sequences. Mol. Brain Res. 1993;18:87-99.

Lengeling A., W.E. Zimmer, S.R. Goodman, Y. Ma, M.L. Bloom, G. Gruneau, M. Krieger, J. Thibault, K. Kaupmann and H. Jockusch. Exclusion of two Candidate Genes, SpnB-2 and Ddc, for the Wobbler Spinal Muscular Atrophy Gene on Proximal Mouse Chromosome 11. Mammalian Genome 1994;5Z:163-166.

Clark M.B., Y. Ma, M. Bloom, J. Barker, I. Zagon, W.E. Zimmer, and S.R. Goodman. Brain b Erythroid Spectrin:  Identification , Compartmentalization, and b-spectrin Association. Brain Research 1994;663:223-236.

Shartava A., C.A. Monteiro, F.A. Bencsath, K. Schneider, B.T. Chait, R. Gussio, L.A. Casoria-Scott, A.K. Shah, C.A. Heuerman and S.R. Goodman. A Posttranslational Modification of b-actin Contributes to the Slow Dissociation of the Spectrin-Protein 4.1-Actin Complex of Irreversibly Sickled Cells. J. Cell Biol. 1995;128:805-815.

Goodman, S.R., W.E. Zimmer, M.B. Clark, I.S. Zagon, J.E. Barker and M.L. Bloom. Brain Spectrin: Of Mice and Men. Brain Res. Bul. 1995;36:593-606.

Zimmer, W.E. and S.R. Goodman. Brain Spectrin. Encyclopedia Human Biol. (R. Dulbecco, Ed.) Academic Press, Vol. 3 (in press).

Shartava, A., P. Miranda, A. Shah, C.A. Monteiro and S.R. Goodman. High Density Sickle Cell Erythrocyte Core Membrane Skeletons Demonstrate Slow Temperature Dependent Dissociation. Am. J. Hematol. 1996;51:215-220.

Goodman, S.R. The Role of the Membrane Skeleton in Formation of the Irreversibly Sickled Cell: A Review. Cellular & Molecular Biol. Letters 1996;1:105-112.

Bencsath, F.A., A. Shartava, C.A. Monteiro, and S.R. Goodman. Identification of the b-Actin Disulfide-linked Peptide which Leads to the Slow Dissociation of the Irreversibly Sickled Membrane Skeleton. Biochemistry 1996;35:4403-4408.

Monteiro, C.A. and S.R. Goodman. Structural Defect in Irreversibly Sickled Cell Alpha Spectrin Demonstrated by a Rabbit Autoantibody. Blood (in press).

Shartava, A., W. Korn and S.R. Goodman. Irreversibly Sickled Cell b-Actin: Defective Filament Formation. Am. J. Hematology 1997;55:97-103.

Gibson, X.A., Y. Zhang, J. Mcintyre, A. Shah, N. Campbell, S.R. Goodmen. The Efficacy of Reducing Agents or Antioxidants in Blocking the Formation of Irreversibly Sickled Cells In Vitro Blood (inpress).

Wang, G., X. Xu, B.S. Pace, P.M. Glazer, P. Chan, I. Shokolenko, and S.R. Goodman. Inducing Endogenous Human g -Globin Gene Expression by Peptide Nucleic Acids (PNAs). Biochemistry (submitted).

Pace, B.S., Y.R. Chen, A. Thompson, and S.R. Goodman. Truncation Analysis of Butyrate Inducible Elements in the Human Ag Globin Gene Promoter. Journal of Biological Chemistry (submitted).

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